Vibrational Circular Dichroism

Vibrational Circular Dichroism (VCD) is the differential absorption between left and right circularly polarized light (A = ALCP – ARCP). It is a measurement of the optical activity for chiral molecules.


PEM Setting: quarter-wave retardation (λ/4)
Polarization Modulation: right and left circular polarization
Lock-in reference: PEM’s 1st harmonic


Structural study and chiral analysis in chemistry; biochemistry; drug and pharmaceutical industry




L. A. Nafie, T. A. Keiderling and P. J. Stephens, “Vibrational circular dichroism,” J. Amer. Chem. Soc. 98, 2715 (1976)

T. A. Keiderling, in Practical Fourier Transform Infrared Spectroscopy, ed. J. R. Ferraro and K. Krishnan, (Academic, San Diego, 1990) p.203

L. A. Nafie and D. W. Vidrine in Fourier Transform Infrared Spectroscopy, Vol. 3, J. R. Ferraro and L. J. Basile, Eds., (Academic, New York, 1982) p. 83

D. Tsankov, T. Eggimann and H. Weiser, Appl. Spectr. 49, 132 (1995)

Vibrational Circular Dichroism
PEM-based Vibrational Circular Dichroism

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